| REN |
| LOCUS ID | 5972 | |||||||||||||
| GENE_SYMBOL | REN | |||||||||||||
| GENE NAME | renin | |||||||||||||
| SYNONYMNS | HNFJ2 | |||||||||||||
| CHROMOSOME | 1 | |||||||||||||
| HOMOLOGENE ID | 20151 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the u |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. The data suggest that the REN C4280A (rs5705) polymorphism plays an important role in the risk of developing CAD with the highest risk for C allele, but do not support its role as a risk factor for developing restenosis after coronary stenting. | 26102248 |
| Atherosclerosis | 1. The renin-angiotensin system (RAS) also plays an important role in the advancement of atherosclerosis by influencing on physiology of the endothelium, inflammatory reactions, thrombosis, and oxidant injury[9,10] | 26322175 |