ROCK2
LOCUS ID9475
GENE_SYMBOLROCK2
GENE NAMERho associated coile
SYNONYMNSROCK-II
CHROMOSOME2
HOMOLOGENE ID21010
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1. both Rho kinase signaling and oxidative stress are involved in the pathogenesis of a number of human diseases, such as diabetes mellitus, hypertension, and atherosclerosis.25752964