RPS12
LOCUS ID6206
GENE_SYMBOLRPS12
GENE NAMEribosomal protein S12
SYNONYMNSS12
CHROMOSOME6
HOMOLOGENE ID110750
microRNAsNANA
GENE SUMMARY
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 R species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal cancers compared to matched normal colonic mucosa has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. including RPS12, LIMK2, and SFI1 are strong candidates for diabetic nephropathy.21150874