| RPS6 |
| LOCUS ID | 6194 | ||||||||||
| GENE_SYMBOL | RPS6 | ||||||||||
| GENE NAME | ribosomal protein S6 | ||||||||||
| SYNONYMNS | S6 | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 85949 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 R species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-termil serine residues phosphorylated by dif |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These findings suggest the possibility that resveratrol exerts antiproliferative, antihypertrophic effects by activating AMPK and reducing 4E-BP1 and S6 phosphorylation, thus suppressing the development and progression of DN. | 20332614 |