RREB1
LOCUS ID6239
GENE_SYMBOLRREB1
GENE NAMEras responsive element binding protein 1
SYNONYMNSHNT, FINB, LZ321, Zep-1, RREB-1
CHROMOSOME6
HOMOLOGENE ID2218
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a zinc finger transcription factor that binds to RAS-responsive elements (RREs) of gene promoters. It has been shown that the calcitonin gene promoter contains an RRE and that the encoded protein binds there and increases expression of calcitonin, which may be involved in RaRaf-mediated cell differentiation. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. We posit that variants in RREB1 modulate seemingly disparate phenotypes (i.e. T2D, T2D-ESKD and non-T2D-ESKD) through altered activity ing from splice site and missense variants.25027322