S100A12
LOCUS ID6283
GENE_SYMBOLS100A12
GENE NAMES100 calcium binding
SYNONYMNSp6, CAGC, CGRP, MRP6, CA
CHROMOSOME1
HOMOLOGENE ID48361
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity. [provided by RefSeq, Nov 2014]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. High S100A12 levels are associated with the presence and severity of coronary artery disease (CAD) in patients with T2DM.23609464
Retinopathy1. The plasma levels of S100A12 are closely associated with the presence of DR and might be a better biomarker for DR and the prediction of future macrovascular events.26132777