| SELE |
| LOCUS ID | 6401 | ||||||||||
| GENE_SYMBOL | SELE | ||||||||||
| GENE NAME | selectin E | ||||||||||
| SYNONYMNS | ELAM, ESEL, CD62E, ELAM1, LECAM2 | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 389 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesi |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Concentrations of sE-selectin were higher in Type II diabetes patients than in control subjects, and correlated with MDMP, PDMP, plt-CD62P, and plt-CD63 levels in nephropathy patients. | 12032632 |