SEMA3A
LOCUS ID10371
GENE_SYMBOLSEMA3A
GENE NAMEsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SYNONYMNSHH16, SemD, COLL1, SEMA1, SEMAD, SEMAL, coll-1, Hsema-I, S
CHROMOSOME7
HOMOLOGENE ID31358
microRNAsNANA
GENE SUMMARY
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axol outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Here, using immunohistochemistry, we show increased podocyte SEMA3A in renal biopsies from patients with advanced DN.25475434