SERPINF2
LOCUS ID5345
GENE_SYMBOLSERPINF2
GENE NAMEserpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member
SYNONYMNSAAP, API, PLI, A2AP, ALPHA-2-PI
CHROMOSOME17
HOMOLOGENE ID719
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The plasma concentrations of TM and plasmin-alpha 2-antiplasmin complex (PAP) were obviously increased in patients with diabetic nephropathy.11020468