SETD7
LOCUS ID80854
GENE_SYMBOLSETD7
GENE NAMESET domain containing (lysine methyltransferase) 7
SYNONYMNSKMT7, SET7, SET9, SET7/9
CHROMOSOME4
HOMOLOGENE ID12741
microRNAsNANA
GENE SUMMARY
NA

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. SET7/9 gene silencing with siRNAs significantly attenuated TGF- beta 1-induced ECM gene expression. Furthermore, a TGF-beta 1 antibody not only blocked HG-induced ECM gene expression but also reversed HG-induced changes in promoter H3Kme levels and SET7/9 occupancy. Taken together, these show the functional role of epigenetic chromatin histone H3Kme in TGF-beta1-mediated ECM gene expression in mesangial cells under normal and HG conditions. Pharmacologic and other therapies that reverse these modifications could have potential renoprotective effects for diabetic nephropathy.20930066
Cardiovascular1. Within this context, SET domain-containing (lysine methyltransferase) 7 (SET7, also called KMT7, SETD7, SET9) is of increasing significance due to its diverse roles in biological functions and diseases, such as diabetes, cancers, alopecia areata, atherosclerotic vascular disease, HIV, and HCV.26390175