SFRP5
LOCUS ID6425
GENE_SYMBOLSFRP5
GENE NAMEsecreted frizzled re
SYNONYMNSSARP3
CHROMOSOME10
HOMOLOGENE ID2268
microRNAsNANA
GENE SUMMARY
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Cardiovascular1. CONCLUSIONS: Higher serum SFRP5 was inversely associated with multiple risk factors for type 2 diabetes and cardiovascular diseases.29674475
Insulin resistance and inflammation1. Plasma SFRP5 levels were negatively correlated with BMI, WC, WHR, fasting plasma glucose, HbA1C, triglyceride (TG), FINS, HOMA-IR and IL-6. Multiple stepwise regression analysis showed that HOMA-IR, BMI and TG were independently related with plasma SFRP5 levels.23290274