SGK1
LOCUS ID6446
GENE_SYMBOLSGK1
GENE NAMEserum/glucocorticoid regulated kinase 1
SYNONYMNSSGK
CHROMOSOME6
HOMOLOGENE ID48364
microRNAsNANA
GENE SUMMARY
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several altertively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Dracorhodin perchlorate can inhibit high glucose-induced serum and glucocorticoid induced protein kinase 1 (SGK1) and fibronectin(FN) expression in human mesangial cells, and this may be part of the mechanism of preventing and treating renal fibrosis of DN.20931854