SIGLEC1
LOCUS ID6614
GENE_SYMBOLSIGLEC1
GENE NAMEsialic acid binding Ig-like lectin 1, sialoadhesin
SYNONYMNSSN, CD169, SIGLEC-1, dJ1009E24.1
CHROMOSOME20
HOMOLOGENE ID124458
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Altertive splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length ture of this variant has not been determined. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The present findings suggest that sialoadhesin-positive macrophages may contribute to the progression of diabetic nephropathy.22526486