| SIRT6 |
| LOCUS ID | 51548 | ||||||||||
| GENE_SYMBOL | SIRT6 | ||||||||||
| GENE NAME | sirtuin 6 | ||||||||||
| SYNONYMNS | SIR2L6 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 6924 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombition of rD. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Altertive splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy. In addition, SIRT3 and SIRT6 are implicated in age-related disorders or longevity. In the present review, we discuss the protective functions of sirtuins and the association of sirtuins with the pathophysiology of renal diseases, including diabetic nephropathy. | 23075334 |