SIRT6
LOCUS ID51548
GENE_SYMBOLSIRT6
GENE NAMEsirtuin 6
SYNONYMNSSIR2L6
CHROMOSOME19
HOMOLOGENE ID6924
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombition of rD. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Altertive splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Therefore the activation of SIRT1 in the kidney may be a new therapeutic target to increase resistance to many causal factors in the development of renal diseases, including diabetic nephropathy. In addition, SIRT3 and SIRT6 are implicated in age-related disorders or longevity. In the present review, we discuss the protective functions of sirtuins and the association of sirtuins with the pathophysiology of renal diseases, including diabetic nephropathy.23075334