| SLC22A6 |
| LOCUS ID | 9356 | ||||||||||
| GENE_SYMBOL | SLC22A6 | ||||||||||
| GENE NAME | solute carrier famil | ||||||||||
| SYNONYMNS | OAT1, PAHT, HOAT1, ROAT1 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 16813 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Notably, organic anion transporter-1 (OAT1) knockout mice expressed a similar pattern of reduced levels of Urinary organic acids, and human kidney tissue from patients with diabetic nephropathy demonstrated lower gene expression of OAT1 and OAT3. | 23949796 |