SLC22A6
LOCUS ID9356
GENE_SYMBOLSLC22A6
GENE NAMEsolute carrier family 22 (organic anion transporter), member 6
SYNONYMNSOAT1, PAHT, HOAT1, ROAT1
CHROMOSOME11
HOMOLOGENE ID16813
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Notably, organic anion transporter-1 (OAT1) knockout mice expressed a similar pattern of reduced levels of Urinary organic acids, and human kidney tissue from patients with diabetic nephropathy demonstrated lower gene expression of OAT1 and OAT3.23949796