SLC2A2
LOCUS ID6514
GENE_SYMBOLSLC2A2
GENE NAMEsolute carrier family 2 member 2
SYNONYMNSGLUT2
CHROMOSOME3
HOMOLOGENE ID68047
microRNAsNANA
GENE SUMMARY
This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectiol glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Altertive splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Increased GLUT2 gene expression in the renal proximal tubule of diabetic rats is an adaptive condition, which may be important in the diabetic nephropathy development.15869838