SLC2A4
LOCUS ID6517
GENE_SYMBOLSLC2A4
GENE NAMEsolute carrier family 2 member 4
SYNONYMNSGLUT4
CHROMOSOME17
HOMOLOGENE ID74381
microRNAsmiR-106b, 27a27165190
GENE SUMMARY
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Here we identify the insulin downstream effector GLUT4 as a key modulator of podocyte function in diabetic nephropathy (DN).GLUT4 deficiency in podocytes affects podocyte nutrient sensing, in fewer and larger cells, and protects mice from the development of DN.24101677
Cardiovascular1. As such, this process is a target for therapeutic strategies aiming at increasing glucose uptake in insulin-resistant and/or diabetic hearts. AMP-activated protein kinase (AMPK) and its upstream kinases form part of a signaling axis essential for contraction-induced GLUT4 translocation.26138758
Neuropathy1. GLUT4 function is impaired in obesity and type 2 diabetes leading to hyperglycemia and an increased risk of cardiovascular disease and neuropathy.25596527