SLC9A1
LOCUS ID6548
GENE_SYMBOLSLC9A1
GENE NAMEsolute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SYNONYMNSAPNH, NHE1, LIKNS, NHE-1, PPP1R143
CHROMOSOME1
HOMOLOGENE ID20660
microRNAsNANA
GENE SUMMARY
This gene encodes a +/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Increased expression of Na(+)/H(+) exchanger (NHE) and Na(+),K(+)-ATPase activity have been demonstrated in diabetic nephropathy and are implicated in the development of hypertension20003708