SLMAP
LOCUS ID7871
GENE_SYMBOLSLMAP
GENE NAMEsarcolemma associated protein
SYNONYMNSSLAP
CHROMOSOME3
HOMOLOGENE ID31428
microRNAsNANA
GENE SUMMARY
This gene encodes a component of a conserved striatin-interacting phosphatase and kinase complex. Striatin family complexes participate in a variety of cellular processes including sigling, cell cycle control, cell migration, Golgi assembly, and apoptosis. The protein encoded by this gene is a coiled-coil, tail-anchored membrane protein with a single C-termil transmembrane domain that is posttranslatiolly inserted into membranes. Mutations in this gene are associated with Brugada syndrome, a cardiac channelopathy. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. SLMAP rs17058639 C > T polymorphism also had a predictive role for the severity of DR. Haplotype Crs17058639Trs1043045Ars1057719 was associated with the increased risk for DR among Qataris with T2DM. The data suggests the potential role of SLMAP SNPs as a risk factor for the susceptibility of DR among T2DM patients in the Qatari population25880194