| SMAD1 |
| LOCUS ID | 4086 | ||||||||||
| GENE_SYMBOL | SMAD1 | ||||||||||
| GENE NAME | SMAD family member 1 | ||||||||||
| SYNONYMNS | BSP1, JV41, BSP-1, JV4-1, MADH1, MADR1 | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 21196 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the sigls of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, devel |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Smad1 has previously been shown to play a key role in the development of diabetic nephropathy (DN), by increasing synthesis of extracellular matrix. These results provide a new evidence that the TCF7L2/ALK1/Smad1 pathway plays a key role in the development of DN. | 20803090 |