SMAD7
LOCUS ID4092
GENE_SYMBOLSMAD7
GENE NAMESMAD family member 7
SYNONYMNSCRCS3, MADH7, MADH8
CHROMOSOME18
HOMOLOGENE ID4314
microRNAsmiR-2123292313
GENE SUMMARY
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1.MiRNA-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7.26415649