SMG1
LOCUS ID23049
GENE_SYMBOLSMG1
GENE NAMESMG1 phosphatidylinositol 3-kinase-related kinase
SYNONYMNSATX, LIP, 61E3.4
CHROMOSOME16
HOMOLOGENE ID56697
microRNAsNANA
GENE SUMMARY
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Altertively spliced transcript variants have been described, but their full-length ture has yet to be determined. [provided by RefSeq, Mar 2013]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. ATX-AGK-LPA signaling axis might be an important player in the development and progression of diabetic retinopathy22864860