SOCS1
LOCUS ID8651
GENE_SYMBOLSOCS1
GENE NAMEsuppressor of cytokine signaling 1
SYNONYMNSJAB, CIS1, SSI1, TIP3, CISH1, SSI-1, SOCS-1
CHROMOSOME16
HOMOLOGENE ID2776
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine sigling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine sigling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal posttal growth and survival. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In vivo, intrarel delivery of adenovirus expressing SOCS1 and SOCS3 to diabetic rats significantly improved renal function and reduced renal lesions associated with diabetes, such as mesangial expansion, fibrosis, and influx of macrophages. Suppression of the JAK/STAT pathway by increasing intracellular SOCS proteins may have therapeutic potential in diabetic nephropathy20185635
Tuberculosis1. We studied gene expression in peripheral blood cells of patients with diabetes (n = 10) and healthy endemic controls (EC, n = 11) both with and without MTB infection. Mycobacterial antigen (PPD) and mitogen-stimulated SOCS1, SOCS3, interferon-gamma (IFN-?), IL-6, and tumor necrosis factor alpha (TNF?) mRNA expression levels were determined using real-time polymerase chain reaction.28043584