SOCS2
LOCUS ID8835
GENE_SYMBOLSOCS2
GENE NAMEsuppressor of cytokine signaling 2
SYNONYMNSCIS2, SSI2, Cish2, SSI-2, SOCS-2, STATI2
CHROMOSOME12
HOMOLOGENE ID2880
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/sigl transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or sigl-transducing proteins via ubiquitition. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell sigling. This gene has pseudogenes on chromosomes 20 and 22. Altertive splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Suppressor of cytokine signaling (SOCS) 2 has recently been indicated to be involved in the pathogenesis of DN, however, the exact regulatory mechanisms remain unclear. the present research demonstrates that SOCS2 reduces renal lesions associated with diabetes in rats.24802166