SOST
LOCUS ID50964
GENE_SYMBOLSOST
GENE NAMEsclerostin
SYNONYMNSCDD, VBCH, SOST1
CHROMOSOME17
HOMOLOGENE ID11542
microRNAsNANA
GENE SUMMARY
Sclerostin is a secreted glycoprotein with a C-termil cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a mild

OBSERVATIONS

Complication Evidence PMID
Atherosclerosis1.Circulating sclerostin is increased in T2DM patients with atherosclerotic lesions.23288857
Cardiovascular1. These suggest that sclerostin may be involved in the association of mineral and bone disorder with vascular calcification in hemodialysis patients.INTRODUCTIONSevere abdomil aortic calcifications are predictive of high cardiovascular mortality in maintence hemodialysis (MHD) patients.25910747
Nephropathy1. Grem1, SOST, and USAG1 have been demonstrated to be upregulated and play a critical role in the progression of diabetic nephropathy (DN); however, the expression and the role of other DAN family members in DN have not been reported yet.30831151
Neuropathy1. Grem1, SOST, and USAG1 have been demonstrated to be upregulated and play a critical role in the progression of diabetic nephropathy (DN); however, the expression and the role of other DAN family members in DN have not been reported yet.30831151