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SOST |
LOCUS ID | 50964 | |||||||||||||||||||
GENE_SYMBOL | SOST | |||||||||||||||||||
GENE NAME | sclerostin | |||||||||||||||||||
SYNONYMNS | CDD, VBCH, SOST1 | |||||||||||||||||||
CHROMOSOME | 17 | |||||||||||||||||||
HOMOLOGENE ID | 11542 |
microRNAs | NA | NA |
GENE SUMMARY |
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Sclerostin is a secreted glycoprotein with a C-termil cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a mild |
OBSERVATIONS |
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Complication | Evidence | PMID |
Atherosclerosis | 1.Circulating sclerostin is increased in T2DM patients with atherosclerotic lesions. | 23288857 |
Cardiovascular | 1. These suggest that sclerostin may be involved in the association of mineral and bone disorder with vascular calcification in hemodialysis patients.INTRODUCTIONSevere abdomil aortic calcifications are predictive of high cardiovascular mortality in maintence hemodialysis (MHD) patients. | 25910747 |
Nephropathy | 1. Grem1, SOST, and USAG1 have been demonstrated to be upregulated and play a critical role in the progression of diabetic nephropathy (DN); however, the expression and the role of other DAN family members in DN have not been reported yet. | 30831151 |
Neuropathy | 1. Grem1, SOST, and USAG1 have been demonstrated to be upregulated and play a critical role in the progression of diabetic nephropathy (DN); however, the expression and the role of other DAN family members in DN have not been reported yet. | 30831151 |