SPARC
LOCUS ID6678
GENE_SYMBOLSPARC
GENE NAMEsecreted protein, acidic, cysteine-rich (osteonectin)
SYNONYMNSON, BM-40
CHROMOSOME5
HOMOLOGENE ID31132
microRNAsNANA
GENE SUMMARY
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1.SPARC is associated with diabetes complications such as diabetic retinopathy and nephropathy, conditions that are ameliorated in the Sparc-knockout mouse model. As a regulator of the extracellular matrix, SPARC also contributes to adipose-tissue fibrosis.20195270
Retinopathy1. SPARC is associated with diabetes complications such as diabetic retinopathy and nephropathy, conditions that are ameliorated in the Sparc-knockout mouse model. As a regulator of the extracellular matrix, SPARC also contributes to adipose-tissue fibrosis.20195270