SPP1
LOCUS ID6696
GENE_SYMBOLSPP1
GENE NAMEsecreted phosphoprotein 1
SYNONYMNSOPN, BNSP, BSPI, ETA-1
CHROMOSOME4
HOMOLOGENE ID20156
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is involved in the attachment of osteoclasts to the mineralized bone matrix. The encoded protein is secreted and binds hydroxyapatite with high affinity. The osteoclast vitronectin receptor is found in the cell membrane and may be involved in the binding to this protein. This protein is also a cytokine that upregulates expression of interferon-gamma and interleukin-12. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The results of the present study demonstrate that there is an independent association between plasma levels of OPN, but not N-half OPN, and the presence and severity of nephropathy and CAD in diabetes.21034455
Cardiovascular1. Osteopontin and osteoprotegerin levels in type 2 diabetes and their association with cardiovascular autonomic function.26775555
Retinopathy1. Thrombin-cleaved and noncleaved vitreous OPN levels in patients with DR were increased compared with control subjects, suggesting that OPN plays a potential role in the pathogenesis of diabetic retinal ischemia.17505146