SRC
LOCUS ID6714
GENE_SYMBOLSRC
GENE NAMESRC proto-oncogene, non-receptor tyrosine kinase
SYNONYMNSASV, SRC1, c-SRC, p60-Src
CHROMOSOME20
HOMOLOGENE ID21120
microRNAsNANA
GENE SUMMARY
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignt progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. These data indicate a role for Src in a high glucose-Src-TACE-heparin-binding epidermal growth factor-EGFR-MAPK-sigling pathway to collagen accumulation. Thus, Src may provide a novel therapeutic target for diabetic nephropathy.23942551