| STAT5A |
| LOCUS ID | 6776 | ||||||||||
| GENE_SYMBOL | STAT5A | ||||||||||
| GENE NAME | sigl transducer and | ||||||||||
| SYNONYMNS | MGF, STAT5 | ||||||||||
| CHROMOSOME | 17 | ||||||||||
| HOMOLOGENE ID | 20680 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. A |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. RAGE- and TGF-beta receptor-mediated signals converge on STAT5 and p21waf to control cell-cycle progression of mesangial cells: a possible role in the development and progression of diabetic nephropathy. | 15180953 |