STAT5A
LOCUS ID6776
GENE_SYMBOLSTAT5A
GENE NAMEsigl transducer and activator of transcription 5A
SYNONYMNSMGF, STAT5
CHROMOSOME17
HOMOLOGENE ID20680
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Altertively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. RAGE- and TGF-beta receptor-mediated signals converge on STAT5 and p21waf to control cell-cycle progression of mesangial cells: a possible role in the development and progression of diabetic nephropathy.15180953