| SYP |
| LOCUS ID | 6855 | ||||||||||
| GENE_SYMBOL | SYP | ||||||||||
| GENE NAME | synaptophysin | ||||||||||
| SYNONYMNS | MRX96, MRXSYP | ||||||||||
| CHROMOSOME | X | ||||||||||
| HOMOLOGENE ID | 2391 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. The levels of postsynaptic density protein 95 (PSD-95), growth-associated protein 43 (GAP43), and synaptophysin increased in the spinal dorsal horn of DNP rats and db/db mice and in high glucose-cultured primary spinal neurons. | 30649099 |