| TF |
| LOCUS ID | 7018 | ||||||||||
| GENE_SYMBOL | TF | ||||||||||
| GENE NAME | transferrin | ||||||||||
| SYNONYMNS | TFQTL1, PRO1557, PRO2086 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 68153 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-termil domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/po |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The mean TF, total TFPI and free TFPI antigen concentrations were significantly higher in patients with DM than in controls and the plasma TF concentration was significantly higher in patients with retinopathy or nephropathy than in DM with no complications | 8914465 |