TF
LOCUS ID7018
GENE_SYMBOLTF
GENE NAMEtransferrin
SYNONYMNSTFQTL1, PRO1557, PRO2086
CHROMOSOME3
HOMOLOGENE ID68153
microRNAsNANA
GENE SUMMARY
This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-termil domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The mean TF, total TFPI and free TFPI antigen concentrations were significantly higher in patients with DM than in controls and the plasma TF concentration was significantly higher in patients with retinopathy or nephropathy than in DM with no complications8914465