TLR2
LOCUS ID7097
GENE_SYMBOLTLR2
GENE NAMEtoll-like receptor 2
SYNONYMNSTIL4, CD282
CHROMOSOME4
HOMOLOGENE ID20695
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of inte immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Furthermore, in vivo, streptozotocin-induced diabetic mice exhibited an increase in tubular TLR2 and HMGB1 expression. These collectively suggest that TLR2 is likely to be the predomint long term mediator of NF-KappaB activation in transducing inflammation in diabetic nephropathy.23576640
Cardiovascular1. TLR2 and TLR4 downward signaling causes the production of proinflammatory cytokines that can induce insulin resistance and cardiovascular damage in obesity and type 2 diabetes mellitus.28933050