TNFRSF11B
LOCUS ID4982
GENE_SYMBOLTNFRSF11B
GENE NAMEtumor necrosis factor receptor superfamily member 11b
SYNONYMNSOPG, TR1, OCIF, PDB5
CHROMOSOME8
HOMOLOGENE ID1912
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In multivariate stepwise regression analysis, serum OPG has also been shown to be an independent factor associated with the severity of diabetic nephropathy.26078757
Cardiovascular1. Osteoprotegerin is associated with cardiovascular risk in hypertension and/or diabetes 2. Osteoprotegerin is an indicator of diabetes- and hypertension-associated vascular pathologies as endothelial dysfunction and cardiovascular risk.22050177
RetinopathyThese results indicate that SNPs in the OPG gene may be implicated in the pathogenesis of DR.24228244
Atherosclerosis1. Osteoprotegerin (OPG) acts as a regulatory molecule with increased levels in the early stages of diabetes and atherosclerosis, and is also associated with insulin resistance.25450818
Neuropathy1. Osteoprotegerin (OPG) has been linked to different diabetes complications, including cardiovascular disease, and new findings have indicated a specific role in diabetic peripheral neuropathy, but the exact mechanism is unknown.20536491