TNFRSF1B
LOCUS ID7133
GENE_SYMBOLTNFRSF1B
GENE NAMEtumor necrosis factor receptor superfamily member 1B
SYNONYMNSp75, TBPII, TNFBR, TNFR2, CD120b, TNFR1B, TNFR80, TNF-R75, p75TNFR, TNF-R-II
CHROMOSOME1
HOMOLOGENE ID829
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor siglling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitition and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic sigls. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Genetic variation in or near TNFRSF1B may predispose clinical neuropathy, reduced glycosylated hemoglobin, and increased HDL cholesterol in type 2 diabetes patients11315843