TRAF6
LOCUS ID7189
GENE_SYMBOLTRAF6
GENE NAMETNF receptor associa
SYNONYMNSRNF85, MGC:3310
CHROMOSOME11
HOMOLOGENE ID3395
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Sigls from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases includi

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Treatment of diabetic peripheral neuropathy with sildefil, a phosphodiesterase type 5 inhibitor, augmentedMiRNA-146a expression and decreased levels of IRAK1 and TRAF6 in the DRG neurons. In vitro, blockage of MiRNA-146a in DRG neurons abolished the effect of sildefil on DRG neuron protection and downregulation of IRAK1 and TRAF6 proteins under hyperglycemia. Our data provide the first evidence showing that MiRNA-146a plays an important role in mediating DRG neuron apoptosis under hyperglycemic conditions.24316060
Nephropathy1. Significant association was also found between rs16928973 in TRAF6 gene and diabetic nephropathy (DN) under the allelic model.27062898
Insulin resistance and inflammation1. Overexpression of MVP and its ?-helical domain inhibits the activity of TRAF6 and suppresses macrophage inflammation.30996248