TRH
LOCUS ID7200
GENE_SYMBOLTRH
GENE NAMEthyrotropin releasing hormone
SYNONYMNSTRF, Pro-TRH
CHROMOSOME3
HOMOLOGENE ID5163
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Our findings suggest that TRH has an acute effect on peripheral neuropathy in experimental streptozotocin diabetes in the rat.10414927