TRIB3
LOCUS ID57761
GENE_SYMBOLTRIB3
GENE NAMEtribbles pseudokinase 3
SYNONYMNSNIPK, SINK, TRB3, SKIP3, C20orf97
CHROMOSOME20
HOMOLOGENE ID10902
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Finally, we demonstrate in murine tubular cells that TRB3 can inhibit secretion of IL-6. Thus, TRB3 reduces albuminuria and inflammatory gene expression in diabetic kidney disease by a mechanism that may involve inhibition of the mTORC2/AKT pathway and may prove to be a novel therapeutic target. . Our results indicate that smoking and the TRIB3 G-allele is associated with an increased risk of diabetic nephropathy, which supports the hypothesis that oxidative stress contributes to the development of diabetic nephropathy.24676635 , 25447894
Cardiovascular1. Although preliminary, our finding suggests a role of TRIB3 low-frequency variants on CAD among Italian patients with T2D.26253791