| TRIB3 |
| LOCUS ID | 57761 | |||||||||||||
| GENE_SYMBOL | TRIB3 | |||||||||||||
| GENE NAME | tribbles pseudokinase 3 | |||||||||||||
| SYNONYMNS | NIPK, SINK, TRB3, SKIP3, C20orf97 | |||||||||||||
| CHROMOSOME | 20 | |||||||||||||
| HOMOLOGENE ID | 10902 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Finally, we demonstrate in murine tubular cells that TRB3 can inhibit secretion of IL-6. Thus, TRB3 reduces albuminuria and inflammatory gene expression in diabetic kidney disease by a mechanism that may involve inhibition of the mTORC2/AKT pathway and may prove to be a novel therapeutic target. . Our results indicate that smoking and the TRIB3 G-allele is associated with an increased risk of diabetic nephropathy, which supports the hypothesis that oxidative stress contributes to the development of diabetic nephropathy. | 24676635 , 25447894 |
| Cardiovascular | 1. Although preliminary, our finding suggests a role of TRIB3 low-frequency variants on CAD among Italian patients with T2D. | 26253791 |