| TRIM72 |
| LOCUS ID | 493829 | ||||||||||
| GENE_SYMBOL | TRIM72 | ||||||||||
| GENE NAME | tripartite motif con | ||||||||||
| SYNONYMNS | MG53 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 66924 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| TRIM72 (Tripartite Motif Containing 72) is a Protein Coding gene. Diseases associated with TRIM72 include Miyoshi Muscular Dystrophy and Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2B. Among its related pathways are Smooth Muscle Contraction and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include phosphatidylserine binding. An important paralog of this gene is TRIM69. |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. It is noteworthy that chronic upregulation of MG53 induces insulin resistance and metabolic diseases, such as type 2 diabetes and its cardiovascular complications, by acting as an E3 ligase to mediate the degradation of insulin receptor and insulin receptor substrate-1. | 28432201 |