TRPC1
LOCUS ID7220
GENE_SYMBOLTRPC1
GENE NAMEtransient receptor potential cation channel, subfamily C, member 1
SYNONYMNSTRP1, HTRP-1
CHROMOSOME3
HOMOLOGENE ID2478
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. HNF4 alpha and the Ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathy. 2. To summarize, this study shows that TRPC1 genetic polymorphisms are associated with T2D and DN in T2D in the Han Chinese population.18184923 , 23544998