| TRPC6 |
| LOCUS ID | 7225 | |||||||||||||
| GENE_SYMBOL | TRPC6 | |||||||||||||
| GENE NAME | transient receptor p | |||||||||||||
| SYNONYMNS | TRP6, FSGS2 | |||||||||||||
| CHROMOSOME | 11 | |||||||||||||
| HOMOLOGENE ID | 37944 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Immunohistochemistry showed both increased TRPC6 channel protein and VEGF receptor type 2 (VEGFR-2) protein in podocytes from patients with diabetic nephropathy compared to control subjects. | 21868397 |
| Atherosclerosis | 1. High d-glucose or peroxynitrite significantly increased the expression of TRP canonical type 1 (TRPC1), TRPC3, TRPC5, TRPC6, TRP melastatin type 6 (TRPM6), and TRPM7 mRNA and TRPC3 and TRPC6 proteins. High d-glucose-induced oxidative stress increases TRP expression and calcium influx in human monocytes, pointing to a novel pathway for increased activation of monocytes and hence atherosclerosis in patients with diabetes. | 20068131 |