TRPV1
LOCUS ID7442
GENE_SYMBOLTRPV1
GENE NAMEtransient receptor potential cation channel subfamily V member 1
SYNONYMNSVR1
CHROMOSOME17
HOMOLOGENE ID12920
microRNAsNANA
GENE SUMMARY
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. The accumulation of TRPV1 and TRPV3 in peripheral nerves after injury, in spared axons, matches our previously reported changes in avulsed dorsal root ganglion (DRG). Reduction of TRPV1 levels in nerve fibres in diabetic neuropathy skin may from the known decrease of nerve growth factor (NGF) levels.17521436