| TXN |
| LOCUS ID | 7295 | |||||||||||||
| GENE_SYMBOL | TXN | |||||||||||||
| GENE NAME | thioredoxin | |||||||||||||
| SYNONYMNS | TRX, TRDX, TRX1 | |||||||||||||
| CHROMOSOME | 9 | |||||||||||||
| HOMOLOGENE ID | 128202 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Identification of Trx system abnormalities may lead to innovative approaches to treat multiple CVDs and other pathologies. | 26417924 |
| Atherosclerosis | 1. These data were confirmed in a second study in which patients with carotid atherosclerosis showed higher PRX-1 and TRX plasma levels than healthy subjects (p<0.001 for both). | 26117319 |