TXNIP
LOCUS ID10628
GENE_SYMBOLTXNIP
GENE NAMEthioredoxin interacting protein
SYNONYMNSTHIF, VDUP1, HHCPA78, EST01027
CHROMOSOME1
HOMOLOGENE ID38186
microRNAsmiR-1726858253
GENE SUMMARY
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. TXNIP is associated with activation of oxidative stress and tubulointerstitial fibrosis in diabetic nephropathy.24492284
Retinopathy1. In the pathogenesis of diabetic retinopathy, the genes associated with important enzymes (e.g., mitochondrial superoxide dismutase, matrix metalloproteinase-9 and thioredoxin interacting protein) and transcriptional factors are epigenetically modified, the enzymes responsible for these epigenetic modifications are either activated or inhibited, and the levels of microRNAs are altered.26025281
Atherosclerosis1. The present study showed that plasma levels of TXNIP may be a useful predictor of subclinical atherosclerosis in Type 2 diabetic patients.26026780