UCP2
LOCUS ID7351
GENE_SYMBOLUCP2
GENE NAMEuncoupling protein 2 (mitochondrial proton carrier)
SYNONYMNSUCPH, BMIQ4, SLC25A8
CHROMOSOME11
HOMOLOGENE ID2516
microRNAsNANA
GENE SUMMARY
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The amount of UCP2 protein expression was up-regulated in the kidney from DN mice and genipin treatment inhibited this up-regulation both in vivo and in vitro.22848482
Retinopathy1. It was indicated that UCP2 may be implicated in the pathogenesis of type 2 DM and DR in Chinese population.25396419
Atherosclerosis1. type 2 diabetes is associated with increased risk of cardiovascular disease and atherosclerosis where an increased expression of UCP2 appears to be beneficial.16487034
Neuropathy1. UCP2 promoter gene polymorphism -866 G/A was significantly associated with nerve conduction slowing and vasomotor sympathetic functions. These findings suggest that the higher UCP2 activity related to the A allele has an energy-depleting effect on peripheral nerve function in type 2 diabetic patients.16567833