UNC13A
LOCUS ID23025
GENE_SYMBOLUNC13A
GENE NAMEunc-13 homolog A (C. elegans)
SYNONYMNSMunc13-1
CHROMOSOME19
HOMOLOGENE ID11279
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at sypses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012]

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. Our study indicates that Munc13-1, on account of its role in both insulin and neurotransmitter exocytosis and through its binding properties, may be an important factor contributing to the development or progression of diabetic neuropathy.23830992