| UNC13B |
| LOCUS ID | 10497 | ||||||||||
| GENE_SYMBOL | UNC13B | ||||||||||
| GENE NAME | unc-13 homolog B (C. | ||||||||||
| SYNONYMNS | UNC13, MUNC13, Unc13h2 | ||||||||||
| CHROMOSOME | 9 | ||||||||||
| HOMOLOGENE ID | 31376 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this prot |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. We identified 34 replicated genetic variants. Of these, 21 remained significantly associated with diabetic nephropathy in a random-effects meta-alysis. These variants were in or near the following genesACE, AKR1B1 (two variants), APOC1, APOE, EPO, NOS3 (two variants), HSPG2, VEGFA, FRMD3 (two variants), CARS (two variants), UNC13B, CPVL and CHN2, and GREM1, plus four variants not near genes. The odds ratios of associated genetic variants ranged from 0.48 to 1.70. additional variants were detected in subgroup alysesELMO1 (Asians), CCR5 (Asians) and CNDP1 (type 2 diabetes). | 21127830 |