| UTS2 |
| LOCUS ID | 10911 | |||||||||||||
| GENE_SYMBOL | UTS2 | |||||||||||||
| GENE NAME | urotensin 2 | |||||||||||||
| SYNONYMNS | UII, U-II, UCN2, PRO1068 | |||||||||||||
| CHROMOSOME | 1 | |||||||||||||
| HOMOLOGENE ID | 4939 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been descr |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. The associations between Thr21Met and Ser89Asn polymorphisms in the UTS2 gene and DR strongly suggest that these SNPs may be an important a risk factor for the development of diabetic retinopathy (DR) in Caucasians | 22587369 |
| Atherosclerosis | 1. The of the present study provide the first evidence that increased plasma U-II levels may be associated with the progression of diabetic retinopathy and carotid atherosclerosis in patients with Type 2 diabetes | 18338983 |