UTS2
LOCUS ID10911
GENE_SYMBOLUTS2
GENE NAMEurotensin 2
SYNONYMNSUII, U-II, UCN2, PRO1068
CHROMOSOME1
HOMOLOGENE ID4939
microRNAsNANA
GENE SUMMARY
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. The associations between Thr21Met and Ser89Asn polymorphisms in the UTS2 gene and DR strongly suggest that these SNPs may be an important a risk factor for the development of diabetic retinopathy (DR) in Caucasians22587369
Atherosclerosis1. The of the present study provide the first evidence that increased plasma U-II levels may be associated with the progression of diabetic retinopathy and carotid atherosclerosis in patients with Type 2 diabetes18338983