VDAC1
LOCUS ID7416
GENE_SYMBOLVDAC1
GENE NAMEvoltage dependent anion channel 1
SYNONYMNSPORIN, VDAC-1
CHROMOSOME5
HOMOLOGENE ID107244
microRNAsNANA
GENE SUMMARY
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alterte splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. Label-free quantitative comparison of DN Urinary exosomes vs control group and SRM further validation, resulted in the discovery of a panel of three proteins (AMBP, MLL3 and VDAC1) which changes in DN, opening a new field of research focused to improve diagnosis and follow-up of this pathology.24211404