VDAC2
LOCUS ID7417
GENE_SYMBOLVDAC2
GENE NAMEvoltage dependent anion channel 2
SYNONYMNSPOR
CHROMOSOME10
HOMOLOGENE ID37765
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and altertive splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. In diabetic kidneys, tubulointerstitial nephritis antigen (TIg), voltage-dependent anion-selective channel (VDAC) 1, and VDAC2 were up-regulated in parallel with alterations in expression of proteins with functions in oxidative stress and oxidative phosphorylation (OxPhos) pathways.19634143