VEGFC
LOCUS ID7424
GENE_SYMBOLVEGFC
GENE NAMEvascular endothelial growth factor C
SYNONYMNSVRP, Flt4-L, LMPH1D
CHROMOSOME4
HOMOLOGENE ID3962
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

OBSERVATIONS

Complication Evidence PMID
Retinopathy1. Significant associations were found between VEGFC tag SNPs (individually and within haplotypes) and the presence of any DR or DME in white participants with T1DM and T2DM.26072347