| VEGFC |
| LOCUS ID | 7424 | ||||||||||
| GENE_SYMBOL | VEGFC | ||||||||||
| GENE NAME | vascular endothelial | ||||||||||
| SYNONYMNS | VRP, Flt4-L, LMPH1D | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 3962 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. Significant associations were found between VEGFC tag SNPs (individually and within haplotypes) and the presence of any DR or DME in white participants with T1DM and T2DM. | 26072347 |